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刘翠清简历——博士

发布人:admin资讯来源:沧州医专 发布时间:2017-01-04 09:14:44点击数量:261

 

Curriculum Vitae

刘翠清,女,博士,现任职于浙江中医药大学基础医学院预防医学教研室,教授。浙江省自然科学基金杰出青年基金获得者、浙江省D类钱江人才,浙江中医药大学预防医学学科带头人。研究方向为饮食和环境因素(细颗粒物)对代谢性心血管疾病的影响及防治的研究、炎症在胰岛素抵抗过程中作用的研究、糖尿病血管并发症的机制研究。主持在研国家自然科学基金、留学回国人员启动基金、省自然科学基金等项目多项。参与863子项目、国家基金项目多项。参编教材(Principles of toxicology : environmental and industrial applicationsAir Pollution and Health Effects二部,在Environ Health PerspectParticle & Fibre ToxicologyToxicol SciBiochemical Pharmacology等杂志已公开发表论文30篇,SCI收录文章20篇,其中第一作者和/或通讯作者10余篇,论文总共被引300余次,web of science引用200余次。部分工作被Environ Health Perspectives作为highlight配以专评。2014年获浙江省第八届青年教师教学技能比赛一等奖,指导浙江省大学生新苗人才项目项。澳门大学基金外审专家,Clinical and Experimental Pharmacology and PhysiologyLife ScienceBasic & Clinical Pharmacology&ToxicologyNutrition & DiabetesPLOs ONEToxicology 13SCI杂志审稿专家。

 

工作经历:

浙江中医药大学基础医学院                2015.09-至今                             

杭州师范大学医学院                    2003.08-2015.08           讲师、副教授

美国俄亥俄州立大学医学中心    2010.08-2012.12 博士后(Dr.Sanjay rajagopalan)

香港中文大学医学院    2006.08-2007.07 研究助理   (Dr.Yu Huang)

教育经历:

复旦大学医学院                  2005.08-2008.06        博士学位

河北医科大学                              2000.09-2003.06        硕士学位

河北师范大学                                        1997.10-1999.10                      英语专科(自学)

承德医学院                                            1993.10-1996.10                      护理专科(自学)

沧州卫校                                               1992.09-1995.07                       护理专业

 

发表主要文章:

(1)  Wang H, Wang B, Yin H, Zhang G, Yu L, Kong X, Yuan H, Fang X, Liu Q, Liu C, Shi L. Reduced neurotrophic factor level is the early event before the functional neuronal deficiency in high-fat diet induced obese mice. Brain Dis, 2016, doi:10.1007/s11011-016-9905-z.

(2)  Zhang G, Sun Q, Liu C*. Influencing Factors of Thermogenic Adipose Tissue Activity.Front Physiol. 2016 Feb 5;7:29. doi: 10.3389/fphys

(3)  Liu C, Yavar Z, Sun Q.Cardiovascular Response to Thermoregulatory Challenges. Am J Physiol Heart Circ Physiol. 2015.

(4)  Liu C, Sun Q. Book chapter. Chapter 10. Respiratory Toxicology. Principles of toxicology : environmental and industrial applications. 3st Version. Edited by Phillip L. Williams, Robert C. James, Stephen M. Roberts. New York : Wiley, 2015

(5)  Zhao J, Liu C, Bai Y, Wang TY, Kan H, Sun Q. IKK inhibition prevents PM2.5-exacerbated cardiac injury in mice with type 2 diabetes. J Environ Sci (China). 2015 May 1;31:98-103.

(6)  Wang TY, Liu C, Wang A, Sun Q. Intermittent cold exposure improves glucose homeostasis associated with brown and white adipose tissues in mice. Life Sci. 2015 Oct 15;139:153-9.

(7)  Liu C, Fonken L, Xu X, Wang A, Bai Y, Wang TY,  Maurya S, Periasamy M, Morishita M, Brook R, Harkema J, Ying Z, Sun Q, Randy N, Rajagopalan S. Central IKKβ Inhibition Prevents Air Pollution Mediated Peripheral Inflammation and Exaggeration of Type II Diabetes. Particle & Fibre Toxicology. 2004 Oct 30;11(1):53. doi: 10.1186/s12989-014-0053-5  

(8)  Liu C, Bai Y, Xu X, Sun L, Wang A, Wang TY, Maurya S, Periasamy M, Morishita M, Harkema J, Ying Z, Sun Q, Rajagopalan S. Exaggerated Effect of Particulate Matter in Genetic Type II Diabetes Mellitus. Particle & Fibre Toxicology. 2014 May 30;11:27. doi: 10.1186/1743-8977-11-27

(9)  Liu C, Xu X, Bai Y, Wang TY, Rao X, Wang A, Sun L, Ying Z, Gushchina L, Maiseyeu A, Morishita M, Sun Q, Harkema JR, Rajagopalan S. Air Pollution-Mediated Susceptibility to Inflammation and Insulin Resistance: Influence of CCR2 Pathways in Mice. Environ Health Perspect. 2014 Jan; 122(1):17-26.

(10) Yin H, Ru H, Yu L, Kang Y, Lin G, Liu C, Sun L, Shi L, Sun Q, Liu C*. Targeting of rho kinase ameliorates impairment of diabetic endothelial function in intrarenal artery. Int J Mol Sci. 2013 Oct 14;14(10):20282-98.

(11) Sun L, Liu C, Xu X, Ying Z, Maiseyeu A, Wang A, Allen K, Lewandowski RP, Bramble LA, Morishita M, Wagner JG, Dvonch JT, Sun Z, Yan X, Brook RD, Rajagopalan S, Harkema JR, Sun Q, Fan Z. Ambient fine particulate matter and ozone exposures induce inflammation in epicardial and perirenal adipose tissues in rats fed a high fructose diet. Part Fibre Toxicol. 2013 Aug 22;10(1):43.

(12) Liu C, Ying Z, Harkema J, Sun Q, Rajagopalan S. Epidemiological and Experimental Links between Air Pollution and Type 2 Diabetes. Toxicol Pathol, 2013 Feb;41(2):361-73. 

(13) Liu C, Desikan R, Ying Z, Gushchina L, Kampfrath T, Deiuliis J, Wang A, Xu X, Zhong J, Rao X, Sun Q, Maiseyeu A, Parthasarathy S, Rajagopalan S. Effects of a novel pharmacologic inhibitor of myeloperoxidase in a mouse atherosclerosis model. PLoS One, 7(12):e50767, 2012.

(14) Xu X, Liu C, Xu Z, Tzan K, Wang A, Rajagopalan S, Sun Q. Altered adipocyte progenitor population and adipose-related gene profile in adipose tissue by long-term high-fat diet in mice. Life Sci, 90(25-26):1001-9, 2012.

(15) Xu X, Rao X, Wang TY, Jiang SY, Ying Z, Liu C, Wang A, Zhong M, Deiuliis JA, Maiseyeu A, Rajagopalan S, Lippmann M, Chen LC, Sun Q. Effect of co-exposure to nickel and particulate matter on insulin resistance and mitochondrial dysfunction in a mouse model. Part Fibre Toxicol, 9:40, 2012.

(16) Xu X, Deng F, Guo X, Lv P, Zhong M, Liu C, Wang A, Tzan K, Jiang SY, Lippmann M, Rajagopalan S, Qu Q, Chen LC, Sun Q. Association of systemic inflammation with marked changes in particulate air pollution in Beijing in 2008. Toxicol Lett, 212(2):147-56, 2012.

(17) Ying Z, Desikan R, Xu X, Maiseyeu A, Liu C, Sun Q, Ziouzenkova O, Parthasarathy S, Rajagopalan S. Modified methylenedioxyphenol analogs lower LDL cholesterol through induction of LDL receptor expression. J Lipid Res, 53(5):879-87, 2012.

(18) Maiseyeu A, Badgeley MA, Kampfrath T, Mihai G, Deiuliis JA, Liu C, Sun Q, Parthasarathy S, Simon DI, Croce K, Rajagopalan S. In Vivo Targeting of Inflammation-Associated Myeloid-Related Protein 8/14 Via Gadolinium Immunonanoparticles. Arterioscler Thromb Vasc Biol, 32(4):962-70, 2012.

(19) Xu X, Liu C, Xu Z, Tzan K, Zhong M, Wang A, Lippmann M, Chen LC, Rajagopalan S, Sun Q. Long-term exposure to ambient fine particulate pollution induces insulin resistance and mitochondrial alteration in adipose tissue. Toxicol Sci, 124(1):88-98, 2011.

(20) Liu C, Wong S, Leung F, Tian X, Lau C, Lu L, Yao X, Chen Z, Tai Yao, Huang Y. Roles of phosphodiesterase in TP receptor-mediated inhibition of vasorelaxation in response to cyclic AMP-elevating dilators. Eur J Pharmacol, 632(1-3): 45-51, 2010.

(21) Liu C, Leung F, Wong S, Lau C, Wong T, Lu L, Yao X, Tai Yao, Huang Y.  TP receptor activation impairs endothelial nitric oxide-dependent vasorelaxation: role of Rho kinase in endothelium. Biochemical Pharmacology,78(4): 374-381, 2009.

(22) Liu C, Leung F, Lee V, Lau C, Yao X, Lu L, Tai Yao, Huang Y. Prevention of nitroglycerin tolerance in vitro by T0156, a selective phosphodiesterase type 5 inhibitor. Eur J Pharmacol, 590(1-3):250-4, 2008.

(23) 刘翠清、黄聿、陆利民, 血管紧张素转换酶2-血管紧张素1-7Mas轴对血管作用的研究进展. 生理科学进展. 2007,38(1):43-48.

 

会议论文:

(1)   Arteriosclerosis, Thrombosis and Vascular Biology. 2015.05.79. San Francisco, US. 2015

(2)   Arteriosclerosis, Thrombosis and Vascular Biology. 2014.05.46. Toronto, Canada. 2014

(3)   中国生理学会第24届会员代表大会及学术会议,2014.10.24-27,上海,中国.2014.

(4)   第六届国际与职业医学国际学术研讨会. 2014.10.14-16. 上海,中国. 2014

(5)   AAI Annual Meeting. 2013.05.03-07. Honolulu, Hawaii. 2013

(6)   The 11th International Symposium on Mechanism of Vasodilatation. 2013.10.04-06. Zurich, Switzerland, 2013

(7)   EPA CLARC Annual Meeting. 2012.06.21-22. Boston, US. 2012

(8)   EPA Great Lakes Air Center for Integrated Environmental Research. 2012.10.22-23. East Lansing, Michigan, US. 2012

(9)   Arteriosclerosis, Thrombosis and Vascular Biology. 2012.04.1820. Chicago, Illinois, US. 2012

 

大会报告或特邀报告:

(10)PM2.5 and Insulin Resistance, China One Health Workshop. 2016 上海

(11)Role of CCR2 deletion in PM2.5-mediated insulin resistance: good or bad? 浙江省毒理学会第三届学术年会,2016,宁波

(12)Role of Toll-like Receptor 3 in High Fat Diet-Induced Insulin Resistance in Visceral Adipose Tissue. 二省一市生理学年会,2016 上海

(13)PM2.5 and Insulin Resistance,浙江省预防医学会毒理专业委员会换届及学术交流会,2015,杭州

(14)Toxicity beyond the lung:  connecting PM2.5 and diabetes,二省一市生理学年会,2015 杭州

(15)CCR2PM2.5致胰岛素抵抗中的作用研究,二省一市生理学年会, 2013 南京

(16)第一届 myograph研讨会. 2014.5.21. 上海,中国

(17)The 10th International Symposium on Mechanism of Vasodilatation. 2009.06.0103. Senda, Japan. 2009. 口头报告。

在研主持课题:

(1)    Toll样受体3参与调控PM2.5诱发肝脏胰岛素抵抗和脂质代谢紊乱的机制研究,浙江省自然科学基金杰出青年项目,01/2017-12/2020;课题批准号:LR17H260001

(2)    Toll样受体-3PM2.5诱导胰岛素抵抗中作用及调控机制研究,国家自然科学基金青年项目,01/2015-12/2017;课题批准号:81402646

(3)    肺表面活性蛋白D参与调控PM2.5颗粒诱导血管系统胰岛素抵抗的机制研究,浙江省自然科学基金青年项目,01/2013-12/2015;课题批准号:LQ13H070002

(4)    杭州市高层次留学回国人员创业创新资助项目,01/2014-12/2016

(5)    浙江省钱江人才D类项目,01/2015-12/20175万元

(6)    Toll样受体3在高脂饮食诱发胰岛素抵抗中的作用及调控研究,杭州市科技计划项目,12/2014-12/2016;课题批准号:20140633B36

(7)    留学回国人员启动项目,国家教育部,01/2015-12/2016

指导本科生课题:

(1)    Toll样受体3在肥胖诱发脂肪组织胰岛素抵抗和巨噬细胞极性改变中的调控作用研究,浙江省大学生科技创新项目。01-2015-12/2016

(2)    Fasudil对糖尿病血管内皮损伤的保护机制研究,浙江省大学生科技创新项目。01/2011-12/2012。已经结题。

(3)    其它校级创新项目、挑战杯项目多项。

参与课题(主要完成者)

1Great Lakes Air Center for Integrative Environmental ResearchGrant from NIH & Michigan State University, 1/1/2011 to 12/31/2012课题批准号Grant #60024256PI: Sanjay Rajagopalan负责内容实验方案制定、课题布置、实施、数据整理和论文写作。

2 Diet-Environment Interactions in InflammationGrant from National Institute of Environmental Health Sciences (NIEHS), 9/28/2010-5/31/2012课题批准号Grant #60020639PI: Sanjay Rajagopalan负责内容实验方案制定、课题布置、实施、数据整理和论文写作。

3Development of a New Class of Pharmacological Mediators for Myeloperoxidase Inhibition (NIH), 6/1/2010-5/31/2012课题批准号Grant # R21 DK088522PI: Sanjay Rajagopalan负责内容实验方案制定、课题实施、数据整理和论文写作。

4)白介素-1受体激活调控淀粉样前体蛋白a剪切酶对阿尔茨海默综合征神经保护作用机制研究,国家自然科学基金项目,01/2014-12/2016;课题批准号:81302781

5)其他参与863子项目一项、国家自然科学基金项目一项、市厅级项目若干。

 

奖励情况:

(1)       浙江省高校第八届青年教师教学技能比赛   一等奖    浙江省   2014.7.3

(2)       其它校级、院级奖励若干。

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